КОЛИЧЕСТВЕННЫЕ И МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ ПОПУЛЯЦИИ С-КЛЕТОК ЩИТОВИДНОЙ ЖЕЛЕЗЫ ПОД ВЛИЯНИЕМ ПАКЛИТАКСЕЛА В МОДЕЛИ ДМБА-ИНДУЦИРОВАННОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ
Abstract
Химиотерапия в онкологии представляет собой высокотехнологичный метод лечения злокачественных новообразований, основанный на системном введении фармакологических агентов в организм. Паклитаксел — химиотерапевтический препарат растительного происхождения, относящийся к классу ингибиторов митоза, широко применяемый в терапии злокачественных опухолей. Препарат блокирует клеточное деление, нарушает функцию микротубулярного аппарата и ряда белковых ферментов, а также оказывает негативное влияние на обмен аминокислот, нуклеиновых кислот, биосинтез липидов и процессы клеточного дыхания. В ряде случаев отмечается нарушение хронобиологических ритмов в клетках фолликулярного эпителия щитовидной железы. В связи с этим развитие вторичных патоморфологических изменений щитовидной железы на фоне химиотерапии остаётся одной из актуальных проблем современной клинической медицины.
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