IMMUNOPATHOGENIC MECHANISMS UNDERLYING THE CARDIORESPIRATORY MANIFESTATIONS OF POST-COVID SYNDROME
DOI :
https://doi.org/10.5281/zenodo.17726464Résumé
This study investigates innate and adaptive immune dysregulation in patients with the cardiorespiratory variant of post-COVID syndrome. A comprehensive assessment of clinical symptoms, functional impairment, cytokine profiles, lymphocyte subsets, and endothelial markers was performed. Patients demonstrated persistent activation of pro-inflammatory pathways, reduced regulatory immune activity, and indicators of microvascular dysfunction. These changes were strongly associated with dyspnea, palpitations, decreased exercise tolerance, and prolonged recovery. The findings highlight the central role of immune imbalance in the pathogenesis of the cardiorespiratory variant and suggest that immunological parameters may serve as early predictors of severity and long-term outcomes in post-COVID patients.
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