MOLECULAR ALTERATIONS OF HEPATIC GENE EXPRESSION IN PREGNANT WOMEN WITH FATAL COVID-19

Abstract

This article explores molecular alterations in hepatic gene expression in pregnant women with fatal COVID-19. The study focuses on transcriptional and post-transcriptional changes in liver-related genes induced by SARS-CoV-2 infection under pregnancy-associated immunological and hormonal modulation. Particular attention is given to genes involved in inflammatory signaling pathways, coagulation processes, oxidative stress response, and hepatocellular metabolism. The findings suggest that fatal COVID-19 cases in pregnancy are associated with significant dysregulation of immune-response genes, upregulation of pro-inflammatory cytokines, and suppression of genes responsible for liver regeneration and detoxification. These molecular disturbances contribute to severe hepatic dysfunction and systemic complications. The study highlights the importance of understanding gene expression profiles to elucidate the pathogenesis of COVID-19-related liver injury in pregnant women and to support the development of targeted therapeutic approaches.