ROLE OF XYLOPIR-T POLYPHENOL IN CA²+-TRIGGERED MITOCHONDRIAL MEGAPORE OPENING.

Abstract

Mitochondria are vital organelles responsible for cellular metabolism, and their functional state changes under the influence of calcium ions, reactive oxygen species, and various biologically active compounds. Excessive accumulation of Ca²+ ions in mitochondria triggers the opening of the Ca²+-dependent mitochondrial megapore, leading to membrane potential depolarization and the release of apoptotic proteins. In this study, the effect of the polyphenol Xylopir-T on the process of Ca²+ -induced mitochondrial megapore opening was investigated. The results demonstrated that Xylopir-T polyphenol exhibits dose-dependent inhibitory, membrane-stabilizing, and protective properties against Ca²+ -induced mitochondrial permeability transition.