International Conference on Health & Technology
International Conference on Health & Technology (ICHT) is organized annually online from Berlin, Germany. The event covers Healthcare, Biotechnology, IT & Engineering innovations. Proceedings are indexed in Google Scholar, Zenodo, OpenAIRE, Open Access databases. Articles are accepted in English and German.
ANALYSIS OF COMBINED CLINICAL SYMPTOMS IN PATIENTS WITH GENITAL PROLAPSE ACCOMPANIED BY BENIGN TUMORS OF THE UTERUS AND ITS ADNEXA
This thesis analyzes the clinical manifestation of combined symptoms in patients with genital prolapse accompanied by benign tumors of the uterus and its adnexa. The study is based on clinical materials from 85 patients treated for genital prolapse during 2022-2027. Special attention is given to the fact that, in combined pathology, patient complaints are formed not only by isolated prolapse-related symptoms, but also by mixed symptom complexes involving menstrual disorders, pain, pressure sensation, urinary dysfunction, bowel complaints and sexual dysfunction.
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GENDER-SPECIFIC HORMONAL FEATURES ASSOCIATED WITH COL1A1 rs1800012 GENOTYPES IN PRIMARY EMPTY SELLA SYNDROME
Primary empty sella syndrome (PESS) may be accompanied by variable endocrine disturbances resulting from anatomical and functional changes in the hypothalamic-pituitary system. The present study evaluated hormonal characteristics associated with different genotypes of the COL1A1 rs1800012 polymorphism in women and men with PESS. The analysis included 26 women and 10 men with available molecular-genetic and hormonal data. Among women, 13 had the G/G genotype, 9 the G/T genotype, and 4 the T/T genotype. The most pronounced genotype-related differences involved prolactin. Its concentration was 38.7±4.6 in G/G carriers, 20.9±4.6 in G/T carriers, and 46.0±7.5 in T/T carriers; significant differences were observed between G/T and G/G as well as between T/T and G/T groups (p<0.05). Among men, the T/T genotype was associated with a significantly lower FSH level compared with G/T carriers (2.07±0.10 vs 2.70±0.10; p<0.05), while LH and testosterone also tended to be lower. No consistent genotype-dependent differences were found for TSH or free T4. The results indicate that the association between COL1A1 rs1800012 and the hormonal phenotype of PESS may differ between sexes, involving prolactin predominantly in women and gonadotropic function in men.
DYNAMICS OF NEPHRIN AND CYSTATIN C DURING DIFFERENT GLUCOSE-LOWERING THERAPIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Background. Diabetic kidney disease is a major complication of type 2 diabetes mellitus (T2DM). Current evidence supports the kidney-protective effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors in patients with diabetes and chronic kidney disease [1–4]. Nephrin reflects podocyte injury, whereas cystatin C is a sensitive marker of changes in glomerular filtration. Their combined assessment may provide information on both structural and functional renal changes during treatment. Objective. To compare changes in nephrin and cystatin C during different glucose-lowering treatment regimens in patients with T2DM. Materials and Methods. The study included 140 patients with T2DM receiving combination glucose-lowering therapy. Of these, 62 patients received a DPP-4 inhibitor plus metformin and 78 patients received an SGLT2 inhibitor plus metformin. After 12 months, patients were evaluated according to three treatment regimens: DPP-4 inhibitor + metformin, SGLT2 inhibitor + metformin, and SGLT2 inhibitor + DPP-4 inhibitor + metformin. Clinical, metabolic and renal parameters were assessed, with particular attention to serum nephrin and cystatin C. Results. At baseline, serum nephrin was 8.10 ± 0.78 ng/mL in the DPP-4 inhibitor + metformin group and 6.85 ± 0.95 ng/mL in the SGLT2 inhibitor + metformin group (p<0.05). Serum cystatin C was 16.0 ± 1.03 versus 16.5 ± 0.93 mg/L, respectively (p>0.05). After 12 months, nephrin levels were 6.92 ± 0.64, 4.98 ± 0.58 and 3.86 ± 0.47 ng/mL in the DPP-4 inhibitor + metformin, SGLT2 inhibitor + metformin and triple-therapy groups, respectively (p<0.05). Cystatin C levels were 14.8 ± 0.84, 13.2 ± 0.76 and 12.4 ± 0.69 mg/L, respectively. The greatest reduction in nephrin was observed with triple therapy (43.6%), compared with 27.3% with SGLT2 inhibitor + metformin and 14.6% with DPP-4 inhibitor + metformin. Cystatin C decreased by 24.8%, 20.0% and 7.5%, respectively. Conclusion. Treatment regimens containing an SGLT2 inhibitor were associated with greater reductions in nephrin and cystatin C. The most pronounced biomarker changes were observed with triple therapy combining an SGLT2 inhibitor, DPP-4 inhibitor and metformin. These findings suggest that simultaneous measurement of nephrin and cystatin C may be useful for monitoring structural and functional renal biomarker responses during therapy in patients with T2DM..
STRUCTURE OF DENTAL MORBIDITY AND RISK FACTORS IN ELDERLY AND SENILE PATIENTS
According to the Global Burden of Disease study, the prevalence of dental diseases in individuals aged 70 years and older increased from 133.26 million cases in 1990 to 313.37 million in 2021; this increase is almost entirely attributable to the growth of this population group, and a further rise in the disease burden is expected by 2040 [7]..
SERUM CERAMIDE AS AN INDEPENDENT PREDICTOR OF STEATOSIS GRADE AND FIBROSIS STAGE IN NON-ALCOHOLIC FATTY LIVER DISEASE
The prognosis of non-alcoholic fatty liver disease is determined primarily by the severity of hepatic steatosis and, above all, by the stage of fibrosis, since progressive fibrosis is the principal predictor of adverse liver-related outcomes. Consequently, the clinical value of a laboratory marker depends not only on its ability to detect the presence of disease, but also on its capacity to reflect disease severity. Ceramide participates in lipotoxic injury, mitochondrial dysfunction and the activation of fibrogenesis, which makes it a rational candidate for the stratification of patients according to the risk of progression.
Speed is one of the most important physical qualities for athletes. It depends on how well the nervous system and muscles work together. This study looked at the speed of 294 athletes from sports schools in Karakalpakstan, using a 40 m running test. The athletes were from six sports: football, athletics, volleyball, wrestling, boxing, and basketball. The fastest average speed was found in volleyball players (v = 7.76 m/s). The best ability to keep top speed until the end of the run was found in athletics (track and field) athletes (v_Loss = 1.2%). These results can help coaches understand and improve speed training in different sports.
ANALYSIS OF ANTHROPOMETRIC INDICATORS OF SCHOOL CHILDREN
The physical development of school-age children is one of the most important indicators of population health. Systematic monitoring of the growth patterns of children and adolescents is of great importance in raising a healthy generation and developing preventive medicine. The aim of the study is to analyze the age-related dynamics of the main anthropometric indicators of schoolchildren (boys) aged 7 to 18 years, such as height, body weight, body mass index (BMI), head and chest circumference, and identify critical periods of growth. The study used anthropometric measurement methods and methods of mathematical and statistical analysis of the results obtained.
EFFICIENCY OF IMPLEMENTING DIGITAL TWIN TECHNOLOGY IN INDUSTRIAL ENTERPRISES: OPERATIONAL, ECONOMIC, AND TECHNICAL PERSPECTIVES
In the era of Industry 4.0, the integration of Cyber-Physical Systems (CPS) has revolutionized traditional manufacturing setups. Among these breakthrough technologies, the Digital Twin (DT) stands out as a core paradigm shift. A Digital Twin is a dynamic, real-time virtual representation of a physical asset, process, or system that continuously mirrors its state through synchronized data streams. This paper comprehensively analyzes the operational, economic, and technical efficiency of implementing Digital Twin technology within heavy industrial enterprises.
ICHTHYOMETRIC METHODS AND WEIGHT–LENGTH RELATIONSHIPS FOR ASSESSING THE GROWTH DYNAMICS OF SILVER CARP (HYPOPHTHALMICHTHYS MOLITRIX VALENCIENNES, 1844): A REVIEW
This review summarizes the scientific principles of ichthyometric methods and weight–length relationships used to assess the growth dynamics of silver carp (Hypophthalmichthys molitrix Valenciennes, 1844). The biological significance of morphometric parameters, including body length, body weight, Fulton's condition factor, weight–length regression, and allometric growth models, is discussed in relation to fish growth and physiological condition. Particular attention is given to the application of these methods in broodstock selection, selective breeding, and growth evaluation under pond aquaculture conditions. The reviewed literature indicates that integrated morphometric analysis provides a reliable scientific basis for evaluating growth performance, optimizing feeding strategies, and improving broodstock management in aquaculture.
SOCIO-PSYCHOLOGICAL FACTORS OF EMOTIONAL DEPENDENCE AND THEIR INTERRELATIONSHIP
The rapid development of artificial intelligence (AI) technologies and their widespread integration into all spheres of everyday life have introduced new mechanisms influencing individuals' cognitive, emotional, and social functioning. University students increasingly use AI tools for learning, conducting research, communication, and solving personal problems, which may increase the likelihood of developing emotional attachment and dependence on these technologies. According to the UNESCO Analytical Report (2025), most higher education institutions are developing regulatory frameworks for the use of artificial intelligence. At the same time, excessive reliance on AI, the decline of independent thinking, concerns regarding academic integrity, and the emergence of psychological dependence have been identified as pressing issues [70]. These challenges highlight the necessity of investigating not only the cognitive but also the emotional and socio-psychological consequences of AI use.
DETERMINING THE QUALITY INDICATORS OF THE KLAVIS TABLET
Antibiotic therapy and gastroprotectors play a key role in the treatment of Helicobacter pylori infection. Specifically, for the effective eradication of Helicobacter pylori, the macrolide antibiotic clarithromycin and bismuth tricalcium disitrate, which effectively affects the flame bacterium surrounding the gastric mucosa, are widely used, which ensures high efficacy in combination therapy.
DEVELOPMENT OF A PROGNOSTIC MODEL FOR LONG-TERM SURVIVAL IN LOCALLY ADVANCED GASTRIC CANCER
Despite significant advances in the diagnosis and treatment of gastric cancer, locally advanced gastric cancer (LAGC) remains associated with poor long-term outcomes. The TNM classification remains the principal prognostic tool; however, patients with identical tumor stages often demonstrate markedly different survival rates, indicating that TNM staging alone is insufficient for accurate prognostic assessment.
PSYCHOLOGISCHE UND DIGITALE FAKTOREN DES MENSCHENHANDELS: ANALYZE DER PHÄNOMENE „TRAUMATISCHE BINDUNG“ UND „VIRTUELLE VIKTIMITÄT“
This thesis comprehensively investigates the subjective- psychological and modern digital determinants of human trafficking crimes
STUDY OF THE FUNCTIONAL STATE AND PARENCHYMAL DISEASES OF THE THYROID GLAND IN WOMEN WITH METABOLIC SYNDROME
In modern medicine, the growing prevalence of metabolic syndrome (MS) has become one of the global health problems. The main components of MS – insulin resistance, dyslipidemia, and visceral obesity – cause systemic inflammation and hormonal homeostasis disorders in the body. The mitogenic effect of hyperinsulinemia on thyrocytes via insulin-like growth factor-1 (IGF-1) accelerates proliferative processes (nodular and diffuse goiter) in the thyroid gland (TG) parenchyma.
THE ROLE OF CERTAIN BLOOD COAGULATION SYSTEM FACTORS IN PREDICTING RECURRENT GASTRODUODENAL ULCER BLEEDING
In the structure of complicated forms of ulcer disease, gastroduodenal hemorrhages (GDK) account for 42-47%. Despite the widespread introduction of H-2 receptor antagonists, proton pump inhibitors, and antihelicobacter therapy, the number of patients with disease recurrences and gastroduodenal bleeding is increasing to 60%, and mortality remains above 10%. Between 20 and 220 out of 100,000 people worldwide suffer from stomach and duodenal ulcers, with an annual mortality rate of 246,000. WHO data 2008 (Button L A 2011, Savelyev V C 2013)..
BODY COMPOSITION AND INSULIN RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Obesity is a major risk factor for developing insulin resistance and type 2 diabetes. Individuals with the same BMI may have significant differences in the ratio of total fat and muscle mass. Determining body composition in obese individuals helps to more accurately determine the risk of insulin resistance and type 2 diabetes.
ANALYSIS OF THE SOURCE OF DUSTY AIR EMISSIONS INTO THE ATMOSPHERE
in this thesis, data taxa about the origin of dust, the methods of its occurrence, the composition of dust, the differences between natural and artificial dust, the impact of dust on human health, the impact of dust on human health in industrial enterprises and the latest technologies that prevent dust are highlighted.
REPRESENTATION OF THE CONCEPTS OF WEALTH AND POVERTY IN THE LINGUISTIC WORLDVIEW
This paper investigates the representation of the concepts of wealth and poverty in the Uzbek linguistic worldview from cognitive and linguocultural perspectives. The study analyzes the conceptual content of these notions and examines their realization through lexical, phraseological, and paremiological units. Particular attention is paid to the national and cultural characteristics of these concepts as reflected in the linguistic consciousness of the Uzbek people. Literary texts, phraseological expressions, and proverbs are employed as the primary sources for revealing the conceptual structure of wealth and poverty. The findings demonstrate that, within the Uzbek linguistic worldview, the concepts of wealth and poverty extend beyond their economic meanings and embody moral, spiritual, and cultural values that have developed throughout the historical experience of the nation..
THE USE OF SYMBOLISM AND IMAGERY IN REPRESENTING IDEALS AND ILLUSIONS
This study explores the use of symbolism and imagery in representing ideals and illusions in literature, focusing on The Great Gatsby as the primary object of analysis. The research examines how these literary devices contribute to the development of themes, characterization, and the author's artistic message. By analyzing symbolic objects, recurring images, and descriptive language, the study demonstrates how ideals such as love, success, and the American Dream gradually transform into illusions when confronted with reality. The research is based on descriptive, analytical, and interpretative methods supported by literary criticism and close textual analysis. The findings reveal that symbolism and imagery function not merely as stylistic elements but as essential means of expressing complex psychological, social, and philosophical ideas. The study concludes that the interaction of symbolism and imagery enhances readers' understanding of the novel while emphasizing the universal conflict between aspiration and reality.
CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF ALLERGIC RHINITIS IN PATIENTS WITH CHRONIC HEPATITIS (A 10-YEAR LITERATURE REVIEW)
Allergic rhinitis (AR) is an IgE-mediated chronic inflammation of the nasal mucosa affecting approximately 10–20% of the world population and significantly reducing quality of life. Chronic hepatitis (CH), particularly its viral forms (HBV, HCV), not only damages liver tissue but also causes systemic immune dysregulation. According to current understanding, hepatotropic viruses replicate in lymphoid and non-lymphoid tissues, impairing the function of immunocompetent cells (lymphocytes) and altering the immune response at the organismal level. Therefore, in the setting of AR and CH comorbidity, both the immunological profile of allergic inflammation and its clinical course are expected to be modified, which is of practical importance for diagnosis and treatment selection.
THE ROLE OF PCSK9 INHIBITION IN ACHIEVING XS- LPNP TARGETING INDICATORS IN PATIENTS WITH IBS AND TYPE 2 DIABETES
The aim of the study is to evaluate the effectiveness of incorporating inclisiran into combined hypolipidemic therapy to achieve target levels of LDL-C in patients with ischemic heart disease and type 2 diabetes mellitus
CLINICAL MANIFESTATIONS OF VASOMOTOR RHINITIS
Vasomotor rhinitis is a chronic rhinitis characterized by episodes of sneezing and nasal congestion, as well as profuse watery nasal discharge. The underlying cause is excessive dilation of mucous membrane blood vessels in response to environmental irritants. The nature of vasomotor rhinitis remains unclear. It is believed that impaired vascular tone occurs due to dysfunction of the sympathetic and parasympathetic divisions of the nervous system. In vasomotor rhinitis, the parasympathetic division, which is responsible for vasodilation, predominates. It is estimated that approximately 10% of the population experiences this condition to varying degrees. It is worth noting that vasomotor rhinitis is a hypersensitive reaction to any environmental irritant, unlike allergic rhinitis, which is caused by an immune response to proteins, pollen, pet dander, mold, etc...
MORPHOLOGICAL CHANGES IN THE PREFRONTAL CORTEX IN METABOLIC SYNDROME AND SLEEP DEPRECATION
Morphological changes in the prefrontal cortex in metabolic syndrome and sleep deprivation include reduced dendritic spines, decreased gray matter volume, decreased neuroplasticity, and chronic neuroinflammation. These impairments, compounded by each other, lead to significant cognitive deficits (particularly working memory and self-control) and emotional dysregulation.
IRANIAN HISTORICAL COLLECTIONS IN THE STATE MUSEUM OF ARTS AND THEIR ROLE IN THE DEVELOPMENT OF UZBEKISTAN’S TOURISM POTENTIAL
This article examines collections related to Iranian history preserved in the State Museum of Arts of Uzbekistan, including works of contemporary Iranian art, porcelain artifacts, Persian carpets, miniature paintings, photographic artworks, calligraphy, manuscripts, and other cultural objects. Special attention is given to the history and culture of Iranian art, as well as to the artistic techniques and methods used in the creation of these artifacts. This determines the relevance of the chosen topic. The relevance of this topic is further emphasized by the growing interest of foreign tourists in the museum’s Iranian collections.
THEORETICAL APPROACHES AND COMPLEX INDICATORS SYSTEM FOR ASSESSING THE ECONOMIC EFFICIENCY OF WATER RESOURCES USE IN AGRICULTURE
This thesis analyzes theoretical approaches to assessing the economic efficiency of water resources use in agriculture and a system of complex indicators. The study studies the main economic, environmental and technical indicators used to assess the efficiency of water use and highlights their interrelationships. It also substantiates the need for integrated and systematic approaches to fully assess the efficiency of resource use. As a result, scientific and practical conclusions have been developed on the formation of a system of complex indicators that serve to increase the efficiency of water resources use.
SCIENTIFIC SUBSTANTIATION OF THE DIRECTIONS FOR SORTING AND PROCESSING SEEDS BASED ON RESIDUAL FIBER CONTENT
The text describes the influence of initial moisture (W) and cotton impurity (S) on the ginning process and the amount of residual fiber in the seeds. Experiments conducted at the "Rishtan" cotton ginning enterprise on industrial cotton varieties I-II-III of the S-6524 variety showed that an increase in raw material moisture and contamination complicates the operation of the saw cylinder and directly increases the amount of fiber remaining in the seeds.
GENESIS, MORPHOLOGICAL CHARACTERISTICS, AND MORPHOGENETIC FEATURES OF IRRIGATED MEADOW ALLUVIAL SOILS IN THE AMU DARYA DELTA
The article analyzes the genesis, morphological characteristics, and morphogenetic features of irrigated meadow alluvial soils formed in the ancient Amu Darya delta. The study identified clearly differentiated genetic horizons including humus, transitional, illuvial, and parent material layers. The upper horizon is enriched with organic matter and plant roots, whereas the lower horizons are characterized by increased moisture, carbonate and iron accumulations, and groundwater influence. Furthermore, the results show that alluvial, hydromorphic, biological, and anthropogenic processes play a major role in soil formation and profile differentiation. The research confirms the high agricultural potential of these soils and emphasizes the importance of scientifically based irrigation and soil management practices for maintaining fertility and ecological stability.
THE ROLE OF THE SOCIAL ENVIRONMENT IN SHAPING ATHLETES’ EMOTIONAL AND PSYCHOLOGICAL STATES IN EMERGENCY SITUATIONS
This article examines the socio-psychological factors influencing the formation of athletes’ psychological and emotional states in emergency situations. The study analyzes theories of stress, motivation, adaptation, and emotional stability within sports psychology. Furthermore, coach–athlete relationships, team environment, motivation levels, and social support are identified as the key factors ensuring athletes’ psychological resilience. The findings emphasize the importance of social and psychological support mechanisms in maintaining emotional stability and enhancing athletic performance under stressful conditions.
IMMUNOLOGICAL FEATURES OF YOUNG CHILDREN WITH CANDIDAL AND HERPETIC STOMATITIS
Stomatitis is one of the most common diseases affecting the oral mucosa in young children. Particular attention is given to candidal and herpetic stomatitis due to their high prevalence and tendency to recur. The aim of this study was to evaluate the immune status of children aged 1 month to 3 years with candidal and herpetic stomatitis. A total of 30 children were examined, including patients with candidal and herpetic stomatitis, as well as a control group of apparently healthy children. Differences in humoral and cellular immunity parameters were identified depending on the clinical form of the disease. The obtained results confirm the involvement of immunological mechanisms in the development of stomatitis in young children.