IMMUNOGENETIC FACTORS ON THE DEVELOPMENT OF ALLERGIC RHINITIS

Abstract

One effective approach to studying the role of genetic mechanisms in the development of atopy involves identifying a group of genes, the products of which may be directly or indirectly involved in the development of this pathology, the so-called candidate genes. The greatest difficulty in this regard has proven to be the polygenic nature of AR. Therefore, the traditional "gene-disease" framework for studying AR cannot be used in patients with AR. From a genetic perspective, AR is currently considered a multifactorial polygenic disorder, the hereditary transmission of which is carried out by a group of genes. In the 1980s and 1990s, numerous studies were conducted using molecular genetic methods for the purpose of positional cloning and the study of candidate genes. The main characteristics of the AR phenotype were eosinophilia, atopy, and increased IgE levels [5], resulting from the interaction of multiple gene variants.