CYCLOSPORIN - A DEPENDENT EFFECT OF PLANTAGO MAJOR L. POLYPHENOLS ON LIVER MITOCHONDRIAL MEGAPORE

Abstract

The pathological opening of the mitochondrial permeability transition pore (mPTP) leads to cell death. This study investigated the effects of glucopyr-T and xylopyr-T polyphenolic compounds isolated from Plantago major L. on the mPTP of rat liver mitochondria in a cyclosporin A–dependent manner. The results indicate that these compounds are promising modulators of mPTP activity.