ЭПИГЕНЕТИЧЕСКИЕ И МОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ УСТОЙЧИВОСТИ К ТЕРАПИИ РЕЦИДИВИРУЮЩЕГО ЛАРИНГОТРАХЕИТА У ДЕТЕЙ
DOI:
https://doi.org/10.5281/zenodo.18580159Аннотация
Рецидивирующий ларинготрахеит (РЛТ) у детей остаётся актуальной проблемой педиатрии и оториноларингологии из-за высокой частоты повторных эпизодов, риска стеноза гортани и недостаточной эффективности стандартной противовоспалительной терапии у части пациентов. Несмотря на широкое применение ингаляционных кортикостероидов, у некоторых детей сохраняется высокая частота рецидивов, что указывает на индивидуальные механизмы терапевтической резистентности. Эпигенетические и молекулярные факторы, включая метилирование ДНК и регуляцию экспрессии микроРНК, способны модулировать воспалительный ответ дыхательных путей и влиять на чувствительность к терапии.
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