THE SIGNIFICANCE OF TGF-β1 GENE POLYMORPHISM IN THE CLINICAL COURSE AND TREATMENT OF SYSTEMIC SCLERODERMA
DOI :
https://doi.org/10.5281/zenodo.19449012Résumé
Systemic scleroderma is a chronic autoimmune disease of connective tissue, characterized by progressive fibrosis, microangiopathy and immune disorders. In recent years, the importance of cytokines regulating fibrogenesis, in particular TGF-β1, in the pathogenesis of the disease has been increasing. The aim of this study is to assess the effect of TGF-β1 gene polymorphism on the clinical course and severity of the disease in patients with systemic scleroderma. 30 patients and 10 healthy individuals as a control group were involved in the study. All participants underwent clinical, laboratory and molecular genetic examinations. The distribution of TGF-β1 gene polymorphisms and their association with clinical symptoms, organ involvement, and disease severity were analyzed. According to the results, TGF-β1 gene polymorphisms were found to be more common in patients with systemic scleroderma and were associated with fibrotic changes, diffuse form, and lung involvement. The obtained data showed that TGF-β1 gene polymorphisms have important clinical significance in assessing the prognosis of the disease and choosing an individual treatment strategy.
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