ASSESSMENT OF CLINICAL AND MORPHOLOGICAL FACTORS OF PREMATURE PLACENTAL ABNORMALITY IN WOMEN AT RISK
DOI:
https://doi.org/10.5281/zenodo.17656926Abstract
Premature separation of a normally situated placenta (PSP) remains one of the most severe obstetric pathologies, posing a significant threat to the life and health of both mother and fetus. The aim of this study was to evaluate the clinical and morphological factors contributing to the development of PSP in women at risk. The material was based on data from a comprehensive clinical and morphological study of 47 women diagnosed with PSP. The control group consisted of women with a normal pregnancy and delivery. Morphological examination of the placentas revealed a number of typical changes: areas of extensive intervillous hemorrhage, destruction and fibrinoid necrosis of the trophoblast, pronounced vascular spasm, and endothelial dystrophy. Increased hyalinosis and fibrosis in the chorionic villi, multiple foci of ischemia and necrosis were noted. The data obtained confirm that premature detachment of a normally located placenta is a multifactorial process, rooted in impaired vascular adaptation and degenerative changes in the placental tissue. A comprehensive clinical and morphological assessment allows for the identification of high-risk women and the implementation of timely preventive measures aimed at preserving the pregnancy and preventing obstetric complications..
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