CHARACTERISTICS OF DETERMINING THE DEGREE OF EXPERIMENTAL THYMECTOMY EFFECT ON BONE MARROW

Abstract

The purpose of the study The aim of the experiment was to compare cytogenetic changes in the bone marrow of white outbred rats against the background of thymectomy and to adequately evaluate the results obtained. A total of 80 3-month-old white outbred rats weighing 160-180 g were randomly selected for the study. Against the background of thymectomy, the proliferation activity of bone marrow cells, a decrease in the number of metaphases and prophases, an increase in mitotic pathologies, and an increase in apoptosis were proven to have a negative effect on bone marrow cells at the molecular level, which allowed for cytogenetic changes, an increase in cytotoxic effect, and an increase in the apoptosis process increased the likelihood that changes in the DNA of cells would occur