MULTISYSTEM INTERACTIONS BETWEEN HEPATOBILIARY STATUS, ENDOTHELIAL DYSFUNCTION, IMMUNE DYSREGULATION, CARTILAGE METABOLISM, AND IMAGING FINDINGS IN RHEUMATIC DISEASES

Abstract

Rheumatic and cardiovascular diseases are increasingly recognized as multisystem disorders in which immune dysregulation, endothelial dysfunction, metabolic disturbances, and structural tissue damage interact to determine clinical outcomes. Chronic ischemic heart disease, allergic vasculitis, rheumatoid arthritis, osteoarthritis, and reactive arthritis represent distinct clinical entities; however, they share overlapping pathogenic mechanisms involving vascular integrity, immune activation, extracellular matrix remodeling, and organ-specific involvement.