CLINICAL AND BIOCHEMICAL EVALUATION OF THE ORAL CAVITY IN PATIENTS AFTER MAXILLOFACIAL ONCOLOGIC RESECTIONS UNDERGOING PROSTHETIC TREATMENT

Abstract

Rehabilitation of patients with malignant tumors (MT) and maxillofacial defects (MFD) is a very big problem of today's society. Especially for the purpose of restoration with the use of orthopedic prostheses can cause tumor recurrence, and aresection prosthesis can cause infection of the tissues of the wound bed. It has been established that the presence and level of expression of matrix metalloproteinases (MMP) tissue inhibitors (TIMP) is actively used to study oral hygiene (OH) when determining MMP-8 in gingival fluid and studying chronic periodontitis. Loss of control over the expression /activity of MMP in various pathologies is associated with an immune response to injury, contributes to the progression of the disease and significant tissue damage. Therefore, it is relevant to study the significance of oral fluid (OF) biomarkers both for additional diagnostics and for assessing the effectiveness of complex and reconstructive treatment of acquired defects of the maxillofacial region (MFR)