PREDICTIVE VALUE OF URINARY BIOMARKERS IN EARLY DETECTION OF TUBULOINTERSTITIAL FIBROSIS IN CHRONIC GLOMERULONEPHRITIS
DOI:
https://doi.org/10.5281/zenodo.17732161Abstract
Chronic glomerulonephritis (CGN) is characterized not only by glomerular injury but also by progressive tubulointerstitial fibrosis (TIF), which is the strongest predictor of long-term renal function decline. Recent literature indicates that inflammatory mediators—including TNF-α, IL-6, monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor-β1 (TGF-β1)—play a central role in initiating and sustaining fibrotic processes [1,2].
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