TRANSLATIONAL IMPLICATIONS OF IMMUNE, ENDOTHELIAL, AND FIBROTIC PATHWAYS IN POST-COVID RHEUMATIC DISEASES

Abstract

Translational research bridges fundamental biological mechanisms and clinical application, enabling discoveries at the molecular and cellular level to inform diagnostics, prognostics, and therapeutic strategies. In the context of post-COVID-19 rheumatic diseases, translational approaches have become particularly relevant due to the convergence of immune dysregulation, endothelial injury, fibrotic signaling, and altered tissue metabolism. These mechanisms collectively influence disease onset, progression, and treatment response in ankylosing spondylitis, rheumatoid arthritis, reactive arthritis, osteoarthritis, allergic vasculitis, systemic sclerosis, and patients with chronic ischemic heart disease